Effects and mechanism of total saponins of Psammosilene tunicoids against rheumatoid arthritis / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 419-421, 2006.
Article
in Zh
| WPRIM
| ID: wpr-350923
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antiarthritic effects and the possible mechanism of total saponins of Psammruosilene tunicoids (TSPT) against rheumatoid arthritis (RA).</p><p><b>METHOD</b>After establishing AA rat model, the TSPT'S antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, arthritis index and levels of IL-1beta and TNF-alpha after medication.</p><p><b>RESULT</b>TSPT could effectively inhibits articular swelling, decrease arthritis index and regulate down the content of IL-1beta and TNF-alpha in the inflammatory tissue soak of AA rats.</p><p><b>CONCLUSION</b>TSPT has good antiarthritic effects and the possible mechanism may be related to its down-regulation of IL-1beta and TNF-alpha.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Arthritis, Rheumatoid
/
Saponins
/
Chemistry
/
Interleukin-1
/
Tumor Necrosis Factor-alpha
/
Rats, Wistar
/
Plant Roots
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article