Polycomb group proteins and their roles in regulating stem cell development / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 281-285, 2012.
Article
in English
| WPRIM
| ID: wpr-352914
ABSTRACT
Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators PRC1 (polycomb repressive complex 1) and PRC2 (polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Stem Cells
/
Cell Differentiation
/
Cell Biology
/
Cell Proliferation
/
Polycomb-Group Proteins
/
Polycomb Repressive Complex 1
/
Polycomb Repressive Complex 2
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Type:
Article
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