Effects on micro-vessel density after pre-operative intra-arterial infusion chemotherapy in colorectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 84-86, 2002.
Article
in Zh
| WPRIM
| ID: wpr-354063
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal cancer.</p><p><b>METHODS</b>Twenty-eight patients with colorectal cancer, treated by surgery from February to October 2000, were divided into two groups randomly. There were 12 patients in group A (pre-operative intra-arterial infusion chemotherapy) and 16 in group B (control). Arterial contrast technique was used in group A, then mitromycin 10 mg, 5-Fu 1,000 mg, epirubicin 60 mg were given through Weidner's way.</p><p><b>RESULTS</b>Micro-vessel density in the center, surface of the tumor and adjacent tissue around the tumor were 40.46 +/- 7.06, 52.27 +/- 18.40, 49.92 +/- 8.15 in group A, and 46.09 +/- 12.21, 73.44 +/- 22.06, 51.94 +/- 12.64 in group B. Micro-vessel density on the surface in group A was significantly lower than that of group B (P < 0.05), with no significance between the center and the adjacent tissue.</p><p><b>CONCLUSION</b>Pre-operative intra-arterial infusion chemotherapy is able to reduce micro-vessel density on the surface of colorectal tumor.</p>
Full text:
1
Index:
WPRIM
Main subject:
Preoperative Care
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Infusions, Intra-Arterial
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Colorectal Neoplasms
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Drug Therapy
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Microcirculation
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article