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Effect of Qingkailing injection (QKLI) on complement and RBL-2 H3 cells in virto / 中国中药杂志
Article in Zh | WPRIM | ID: wpr-354168
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Qingkailing injection (QKLI) on complement and RBL-2 H3 cells in virto.</p><p><b>METHOD</b>The mixture of human serums and QKLI were incubated for 30 min in vitro and then the content of SC5 b-9 in the mixture was determined by ELISA. RBL-2 H3 cells were cultured and treated by QKLI. Beta-heosaminidase release rate was measured by coloration method. The content of histamine in supernatant was tested by ELISA.</p><p><b>RESULT</b>The QKLI can reduce the content of SC5 b-9 (P<0.05) and promote the release of beta-heosaminidase and histamine significantly (P<0.05).</p><p><b>CONCLUSION</b>QKLI didn't induce the complement activation, but induced the release of beta-heosaminidase and histamine directly. Therefore, the clinical adverse reactions of QKLI in clinic may be pseudoallergy which had no relation with the activation of complement system.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pharmacology / Complement System Proteins / Drugs, Chinese Herbal / Cell Degranulation / Chemistry / Chemistry, Pharmaceutical / Bodily Secretions / Cell Line, Tumor / Hexosaminidases / Histamine Release Limits: Animals / Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Complement System Proteins / Drugs, Chinese Herbal / Cell Degranulation / Chemistry / Chemistry, Pharmaceutical / Bodily Secretions / Cell Line, Tumor / Hexosaminidases / Histamine Release Limits: Animals / Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article