Preparation of paclitaxel-loaded polybutylcyanoacrylate nanoparticles / 南方医科大学学报
Journal of Southern Medical University
; (12): 763-766, 2010.
Article
in Zh
| WPRIM
| ID: wpr-355024
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of different preparation methods on the encapsulation efficiency (EE) and drug loading (DL) of paclitaxel-loaded polybutylcyanoacrylate nanoparticles (PTX-PBCA-NPs) and optimize the preparation of PTX-PBCA-NPs.</p><p><b>METHODS</b>With DL and EE as the major indexes, the qualities of PTX-PBCA-NPs produced by the interfacial polymerization and emulsion polymerization method were compared. The optimized prescription was obtained by orthogonal design.</p><p><b>RESULTS</b>The ranges of EE of PTX-PBCA-NPs with the two methods were both 94.39%-99.23%. The highest DL with interfacial polymerization was (1.07-/+0.03)%, as compared to (0.86-/+0.01)% with emulsion polymerization. The optimized preparation conditions resulted in the mean size of PTX-PBCA-NPs of 235.6 nm, DL of 0.80%, and EE of 95.71%.</p><p><b>CONCLUSION</b>The EE of PTX-PBCA-NPs prepared by the above two methods is consistent with the requirement of the Pharmacopoeia of China, and PTX-PBCA-NPs containing higher DL can be obtained via interfacial polymerization.</p>
Full text:
1
Index:
WPRIM
Main subject:
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
/
Paclitaxel
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Delayed-Action Preparations
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Enbucrilate
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Nanoparticles
/
Polymerization
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article