Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome / 南方医科大学学报
Journal of Southern Medical University
; (12): 760-762, 2010.
Article
in Zh
| WPRIM
| ID: wpr-355025
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Kidney-Tonifying plus Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in elderly patients with kidney deficiency and blood stasis syndrome.</p><p><b>METHODS</b>Sixty elderly patients with kidney deficiency and blood stasis syndrome were randomized into two groups. Patients in the treatment group received Kidney-Tonifying plus Blood-Promoting Recipe, and those in the control group receive no treatment. The expression of CD11b/CD18, Bcl-2/Bax, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation in peripheral blood leukocytes before and after the treatment were examined using flow cytometry in both groups.</p><p><b>RESULTS</b>The Recipe significantly decreased the levels of CD11b/CD18, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation (P<0.01), and increased the levels of Bcl-2/Bax (P<0.01).</p><p><b>CONCLUSION</b>Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 and Bcl-2/Bax expression in blood leukocytes and improves microcirculatory status, which can be one of the mechanisms underlying its therapeutic effect in elderly patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
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Aging
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Drugs, Chinese Herbal
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CD18 Antigens
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Proto-Oncogene Proteins c-bcl-2
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CD11b Antigen
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Therapeutic Uses
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Drug Therapy
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Bcl-2-Associated X Protein
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Kidney Diseases
Type of study:
Clinical_trials
Limits:
Aged
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Aged80
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article