Association of cytochrome P4502D6 gene polymorphism with the susceptibility of heroin spongiform leucoencephalopathy / 南方医科大学学报
Journal of Southern Medical University
; (12): 572-583, 2010.
Article
in Zh
| WPRIM
| ID: wpr-355068
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the relation between cytochrome P4502D6 (CYP2D6) gene polymorphism and the susceptibility of heroin spongiform leucoencephalopathy (HSLE).</p><p><b>METHODS</b>With polymerase chain reaction-restriction fragment length polymorphism technique, the cytochrome P4502D6 gene polymorphisms were analyzed in HSLE cases and control subjects.</p><p><b>RESULTS</b>The frequencies of CYP2D6 (CYP2D6/C188, CYP2D6/L2938, CYP2D6/G4268) gene mutations were higher in HSLE patients than in the controls.</p><p><b>CONCLUSION</b>The CYP2D6 gene mutation is associated with a high risk of HSLE.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Restriction Fragment Length
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Canavan Disease
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Cytochrome P-450 CYP2D6
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Heroin
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Genetics
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Heroin Dependence
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Mutation
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article