Association of cytochrome P4502D6 gene polymorphism with the susceptibility of heroin spongiform leucoencephalopathy / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To elucidate the relation between cytochrome P4502D6 (CYP2D6) gene polymorphism and the susceptibility of heroin spongiform leucoencephalopathy (HSLE).</p><p><b>METHODS</b>With polymerase chain reaction-restriction fragment length polymorphism technique, the cytochrome P4502D6 gene polymorphisms were analyzed in HSLE cases and control subjects.</p><p><b>RESULTS</b>The frequencies of CYP2D6 (CYP2D6/C188, CYP2D6/L2938, CYP2D6/G4268) gene mutations were higher in HSLE patients than in the controls.</p><p><b>CONCLUSION</b>The CYP2D6 gene mutation is associated with a high risk of HSLE.</p>