Molecular epidemiological characteristics of HIV-1 strains isolated from newly diagnosed MSM subjects (2006-2010) in Beijing, China / 病毒学报
Chinese Journal of Virology
; (6): 138-142, 2014.
Article
in Zh
| WPRIM
| ID: wpr-356625
Responsible library:
WPRO
ABSTRACT
This study aims to analyze the molecular epidemiological characteristics of HIV-1 strains prevailing among men who have sex with men (MSM) in Beijing, China. The pol gene fragments from 250 newly diagnosed HIV-1-infected MSM individuals during 2006-2010 in Beijing were amplified by RT-nested PCR, sequenced, and phylogenetically analyzed. HIV-1 pol gene from 189 individuals were amplified and analyzed; 81 (42. 9%), 3 (1. 6%), 2 (1.0%), 88 (46. 6%), and 15 (7.9%) individuals were infected with HIV-1 subtypes B, B', C, CRF01_AE, and CRF07_BC, respectively. The subtypes B and CRF01_AE could both be grouped into two clusters, and CRFO7_BC strains shared high homology and were presumed to originate from a common ancestor. The HIV-1 circulating in MSM in Beijing had a lower genetic diversity than in heterosexuals. The HIV-1 epidemic (2006-2010) in MSM in Beijing was actually a rapid spread of HIV-1 CRF01 AE and B, or rather native strains of the two viruses.
Full text:
1
Index:
WPRIM
Main subject:
Phylogeny
/
Genetic Variation
/
Virology
/
Molecular Sequence Data
/
HIV Infections
/
China
/
Epidemiology
/
HIV-1
/
Classification
/
Molecular Epidemiology
Type of study:
Diagnostic_studies
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Virology
Year:
2014
Type:
Article