Preparation of Shuxiong micropellets by centrifugal granulation technology / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1147-1150, 2006.
Article
in Zh
| WPRIM
| ID: wpr-356721
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare shuxiong micropellets.</p><p><b>METHOD</b>Shuxiong micropellets were prepared by using a centrifugal granulator. The formulation composition and process factors were optimized investigated by adopting several indices such as size distribution, repose angle, bulk density and friability as indexes.</p><p><b>RESULT</b>The optimal process parameters were as follows. The ratio of fine intermediate product and MCC was 3:1 (w/w), the adhesive agent was 3% HMPC solution, the rotating rate of plate was 200 r x min(-1), the blower rate was 15 x 20 L x min(-1), the rate of air flow was 15 L x min(-1), the spray air pressure was 0.5 MPa, the rotating of spray solution pump was 5-25 r x min(-1) and the rotating rate of powder feed machine was 5-25 r x min(-1).</p><p><b>CONCLUSION</b>Under the optimal conditions, micropellets prepared by using centrifugal granulator hadpossessed prefect shape and surface characteristics and the yield of shuxiong pellets was 90.5%.</p>
Full text:
1
Index:
WPRIM
Main subject:
Particle Size
/
Phenols
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Plants, Medicinal
/
Quinones
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Cellulose
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Centrifugation
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Chalcone
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Chemistry
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Technology, Pharmaceutical
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Ligusticum
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article