miR-520a regulates ErbB4 expression and suppresses proliferation and invasion of esophageal squamous cell carcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 164-168, 2014.
Article
in Zh
| WPRIM
| ID: wpr-356962
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of miR-520a in regulation ErbB4 expression and the biological behavior of esophageal squamous cell carcinoma (ESCC).</p><p><b>METHODS</b>The role of miR-520a in regulating the expression of ErbB4 was investigated by Western blotting and luciferase reporter assay system. The effect of miR-520a on the proliferation and invasion of ESCC cells was detected by MTT and Transwell invasion assay, respectively.</p><p><b>RESULTS</b>Western blotting and luciferase reporter assay revealed that miR-520a down-regulated the expression of ErbB4 in vitro. miR-520a significantly inhibited the proliferation and suppressed the invasion of ESCC cell line Eca109.</p><p><b>CONCLUSION</b>miR-520a regulates the expression of ErbB4 and suppresses the proliferation and invasion of ESCC cells in vitro, suggesting its role as a tumor suppressor.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Esophageal Neoplasms
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Carcinoma, Squamous Cell
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Gene Expression Regulation, Neoplastic
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Cell Movement
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MicroRNAs
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Cell Line, Tumor
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Cell Proliferation
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Receptor, ErbB-4
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Metabolism
Limits:
Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article