Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy
Diabetes & Metabolism Journal
; : 207-211, 2013.
Article
in En
| WPRIM
| ID: wpr-35730
Responsible library:
WPRO
ABSTRACT
Beyond statin therapy for reducing low density lipoprotein cholesterol (LDL-C), additional therapeutic strategies are required to achieve more optimal reduction in cardiovascular risk among diabetic patients with dyslipidemia. To evaluate the effects and the safety of combined treatment with omega-3 fatty acids and statin in dyslipidemic patients with type 2 diabetes, we conducted a randomized, open-label study in Korea. Patients with persistent hypertriglyceridemia (> or =200 mg/dL) while taking statin for at least 6 weeks were eligible. Fifty-one patients were randomized to receive either omega-3 fatty acid 4, 2 g, or no drug for 8 weeks while continuing statin therapy. After 8 weeks of treatment, the mean percentage change of low density lipoprotein (LDL) particle size and triglyceride (TG) level was greater in patients who were prescribed 4 g of omega-3 fatty acid with statin than in patients receiving statin monotherapy (2.8%+/-3.1% vs. 2.3%+/-3.6%, P=0.024; -41.0%+/-24.1% vs. -24.2%+/-31.9%, P=0.049). Coadministration of omega-3 fatty acids with statin increased LDL particle size and decreased TG level in dyslipidemic patients with type 2 diabetes. The therapy was well tolerated without significant adverse effects.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Particle Size
/
Hypertriglyceridemia
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Fatty Acids, Omega-3
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Cholesterol
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Diabetes Mellitus, Type 2
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Dyslipidemias
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Korea
/
Lipoproteins
/
Cholesterol, LDL
Type of study:
Clinical_trials
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Diabetes & Metabolism Journal
Year:
2013
Type:
Article