Meta-analysis of post-transfusion necrotizing enterocolitis in neonates / 中华儿科杂志
Chinese Journal of Pediatrics
; (12): 336-339, 2013.
Article
in Zh
| WPRIM
| ID: wpr-359742
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To quantitatively assess the association between transfusions and the risk of necrotizing enterocolitis (NEC) in neonates.</p><p><b>METHOD</b>Both Chinese and English literature published from Jan. 1985 to Nov. 2011 about the case-control study of the association between transfusions and neonatal NEC were retrieved by searching the electronic resource databases. A meta-analysis was then performed on the comparison and synthesis of findings from included studies. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using RevMan 5.0 software. Sensitivity analysis was conducted and possible publication bias was tested as well.</p><p><b>RESULT</b>A total of 7 case-control studies (480 blood transfusion cases, 2845 control cases) were included. The meta-analysis with a random-effects model found a pooled OR of 3.35 (95% CI 1.54-7.27). Sensitivity analysis showed that OR for post-transfusion NEC within 48 h was 4.21 (95% CI 2.17-8.16). The OR was 4.29 (95% CI 1.39-13.24) after factors such as gestational age and birth weight were de-confounded. The fail-safe number was 263.</p><p><b>CONCLUSION</b>Blood transfusion can increase the risk of NEC in neonates. The clinical application of this conclusion should be cautious due to limited reports. High-quality randomized control trials are still needed for the further proof of the association between blood transfusion and neonatal NEC.</p>
Full text:
1
Index:
WPRIM
Main subject:
Therapeutics
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Infant, Premature
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Bias
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Case-Control Studies
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Odds Ratio
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Epidemiology
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Risk Factors
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Enterocolitis, Necrotizing
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Knowledge Discovery
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Transfusion Reaction
Type of study:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Systematic_reviews
Limits:
Female
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Humans
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Male
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Newborn
Language:
Zh
Journal:
Chinese Journal of Pediatrics
Year:
2013
Type:
Article