Effects of electroacupuncture on the expression of related protein mRNA in the striatum in rats with Parkinson's disease / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 697-701, 2015.
Article
in Zh
| WPRIM
| ID: wpr-360209
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore action mechanism of electroacupuncture (EA) on treatment of Parkinson's disease (PD).</p><p><b>METHODS</b>A total of 40 healthy male SD rats were randomly divided into a normal group, a sham operation group, a model group and an EA group, 10 rats in each group. PD rat model was duplicated by micro injection of 6-hydroxyl dopamine into right striatum of rats, and the rats in the sham operation group were treated with micro injection of 0. 9% NaCl. Rats in the normal group, model group and the sham operation group received no treatment; rats in the EA group were treated by EA at "Fengfu" (GV 16) and "Taichong" (LR 3) with continuous wave, 2 Hz in frequency, 1 mA in intensity for 30 min. The treatment was given once a day for total 2 weeks. Behavioral test was used to evaluate rotational behavior changes of PD rats. RT-PCR method was applied to detect the expression of GFAP (glial fiber acidic protein) mRNA and Cx43 (connexin 43) mRNA in the striatum.</p><p><b>RESULTS</b>The difference of rotational behavior was not significant before and after treatment in the model group (P>0. 05), while that in the EA group was significant (P<0. 01). The expression of GFAP mRNA and Cx43 mRNA in the model group was significantly higher than that in the normal group and sham operation group (all P<0. 01); after EA treatment, the expression of GFAP mRNA and Cx43 mRNA in the EA group was lower significantly than that in the model group (both P<0. 01).</p><p><b>CONCLUSION</b>The action mechanism of EA for prevention and treatment of Parkinson' s disease may be associated with inhibiting the activation of astrocytes.</p>
Full text:
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Index:
WPRIM
Main subject:
Parkinson Disease
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Therapeutics
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Acupuncture Points
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Electroacupuncture
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Astrocytes
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Rats, Sprague-Dawley
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Connexin 43
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Corpus Striatum
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Genetics
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Metabolism
Limits:
Animals
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Humans
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Male
Language:
Zh
Journal:
Chinese Acupuncture & Moxibustion
Year:
2015
Type:
Article