Effect of qishen huoxue granule combined with fluconazole on survival rate of mice with systemic C. albaicans infection / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of Qishen Huoxue Granule (QHG) combined with Fluconazole on the survival rate of mice with systemic C. albaicans (CA) infection.</p><p><b>METHODS</b>Deep CA infection model mice, with normal and low immunity, were established separately by injecting standard strain of CA via caudal vein, and were divided into 4 groups at random, treated by gastrogavage with normal saline (Group A), QHG (Group B) Fluconazole (FCZ, Group C) and QHG + FCZ (Group D) respectively, and a blank group was set up with normal mice for control. The survival time and the total survival rate in 30 days in various groups were recorded.</p><p><b>RESULTS</b>For mice with normal immunity, the survival rate in Group D and C was 79% and 78% respectively, showing no difference between them (P > 0.05). But for those with low immunity, it was 36% and 7% respectively, and the survival rate significantly higher in Group D than in Group C (P < 0.05).</p><p><b>CONCLUSION</b>As compared with those treated with FCZ alone, QHG combined with FCZ can raise the survival rate of the immuno-suppressed mice with systemic CA infection.</p>