Role of Neutrophils in Pulmonary Dysfunction during Cardiopulmonary Bypass / 日本心臓血管外科学会雑誌
Japanese Journal of Cardiovascular Surgery
; : 363-367, 2000.
Article
in Ja
| WPRIM
| ID: wpr-366615
Responsible library:
WPRO
ABSTRACT
To test the hypothesis that neutrophils play a role in lung injury during cardiopulmonary bypass, granulocyte elastase and myeloperoxidase release from pulmonary circulation were measured, as well as the respiratory index, before and after cardiopulmonary bypass. The production of granulocyte elastase and myeloperoxidase in the pulmonary circulation, and the respiratory index also elevated significantly after cardiopulmonary bypass. Furthermore, the level of granulocyte elastase and myeloperoxidase released from pulmonary circulation correlated with the changes of the respiratory index and preoperative pulmonary artery pressure. These data indicate that neutrophils play a major role in pulmonary dysfunction occurring after cardiopulmonary bypass, which is accentuated in patients with pulmonary hypertension.
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Index:
WPRIM
Language:
Ja
Journal:
Japanese Journal of Cardiovascular Surgery
Year:
2000
Type:
Article