Combined Monitoring of rSO2 and SSEP during Cardiopulmonary Bypass and Postoperative Changes in Plasma Levels of S-100.BETA.: Is Diagnostic Sensitivity for Detecting Brain Damage Improved? / 日本心臓血管外科学会雑誌
Japanese Journal of Cardiovascular Surgery
;
: 269-273, 2002.
Article
in Japanese
| WPRIM
| ID: wpr-366783
ABSTRACT
Combined monitoring of rSO<sub>2</sub> and SSEP is routinely performed during cardiopulmonary bypass (CPB), but it is not sensitive enough to detect focal lesions of the brain. Thus, we assessed whether simultaneous measurement of S-100β is able to enhance diagnostic sensitivity or not. Between September 1999 and February 2000, serial measurement of plasma levels of S-100β and SSEP and rSO<sub>2</sub> monitoring during CPB were simultaneously performed in 26 consecutive patients (19 men and 7 women). Ages ranged from 46 to 85 (mean 67±10 years). Neurological complications developed in 5 (19.2%). Among those patients, hemiplegia developed in 2, and dementia, temporary convulsion, and deep coma in 1 each. Three of them showed abnormally low rSO<sub>2</sub> levels during surgery, but no patient showed abnormal change in SSEP waves after surgery. There was no significant difference in S-100β level 1h after CPB between patients associated with or without neurological complications (1.98±0.48 vs. 1.89±1.65), however, its level 24h after CPB remained significantly higher in patients with neurological complications (1.01±1.14 vs. 0.22±0.24). S-100β level 24h after CPB appears to improve diagnostic sensitivity for detecting such focal brain damage lesions as those in which SSEP or rSO<sub>2</sub> are not efficient enough to make a diagnosis. However, further study is required to evaluate how fast it can differentiate patients with and without brain damage.
Full text:
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Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Japanese
Journal:
Japanese Journal of Cardiovascular Surgery
Year:
2002
Type:
Article
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