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Effects of low-frequency electrical stimulation on synaptic plasticity in the contralesional mirror area of the cortex of rats with cerebral infarction / 中华物理医学与康复杂志
Article in Zh | WPRIM | ID: wpr-380344
Responsible library: WPRO
ABSTRACT
Objective To study changes in synaptic plasticity in the contralesional mirror area of the cortexes of rats with cerebral infarction treated by low-frequency electrical stimulation(LFES)and to explore the therapeutic mechanism of LFES on the molecular level.Methods Forty-eight Sprague-Dawley rats were randomly allocated into a LFES group,a placebo group and a sham-operation group.Following middle cerebral artery occlusion(MCAO),rats in the LFES group were treated with LFES for 7 d(20 min/d),while the ones in placebo group were connected with the same LFES device but without electricity.Rats in the sham-operation group were subjected to a MCAO operation without occlusion and then received no special treatment.Synaptic ultra-structures and the expression levels of glia fibrillary acidic protein(CFAP)and synaptophysin in the contralesional mirror area of the cortexes of the rats in each group were measured with electron-microscopy and Western blotting.Results Compared with the placebo group or the rats before treatment,rats treated with LFES exhibited ultra-structural changes in the form of larger curvature of synaptic interfaces and narrower synaptic clefts.GFAP expression levels did not fluctuate significantly,but the expression of synaptophysin was significantly up-regulated.Conclusion LFES treatment can induce active changes in synaptic plasticity in the contralesional mirror area of the cortex of rats after cerebral infarction.
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Full text: 1 Index: WPRIM Type of study: Clinical_trials Language: Zh Journal: Chinese Journal of Physical Medicine and Rehabilitation Year: 2009 Type: Article
Full text: 1 Index: WPRIM Type of study: Clinical_trials Language: Zh Journal: Chinese Journal of Physical Medicine and Rehabilitation Year: 2009 Type: Article