DNA methylation in cancer research progress / 国际肿瘤学杂志

ABSTRACT

DNA methylation is a way of regulating gene expression of eukaryotes. DNA methylation in the regulation of normal cell development and cancer play an important role. There is evidence that in cancer patients compared with normal subjects,the former showed higher tumor suppressor gene methylation and cancer gene abnormality hypomethylation. In a variety of cancer types, related genes that can control cell cycle, proliferation, apoptosis ,metastasis,drug resistance and intracellular signal transduction exsist abnomal methylation.