MicroRNA-126 and tumor / 国际肿瘤学杂志

ABSTRACT

MicroRNAs can post-transcriptionally regulate the expression of their target mRNAs. MicroRNA-126 plays an important role in tumorigeness by targeting EGFL7, HOXA9, IRS-1 and p85-β. Intriguingly, it is downregulated in a wide range of tumors and is testified that it functions as a tumor suppressor in lung cancer, leukemia, breast cancer and ovarian cancer.