Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model
Journal of Korean Neurosurgical Society
; : 323-328, 2011.
Article
in En
| WPRIM
| ID: wpr-38686
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WPRO
ABSTRACT
OBJECTIVE: Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model. METHODS: A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks. RESULTS: The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B. CONCLUSION: This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Fibrosis
/
Cicatrix
/
Failed Back Surgery Syndrome
/
Fibroblasts
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Amnion
/
Laminectomy
Limits:
Animals
/
Humans
Language:
En
Journal:
Journal of Korean Neurosurgical Society
Year:
2011
Type:
Article