Small molecule inhibitors of Bcl-2 proteins:research progress / 国际肿瘤学杂志
Journal of International Oncology
; (12): 579-581, 2010.
Article
in Zh
| WPRIM
| ID: wpr-387501
Responsible library:
WPRO
ABSTRACT
Small molecule inhibitors of Bcl-2 are a novel class of anticancer drugs that target anti-apoptotic proteins. In recent years,small molecule inhibitors such as ABT-737 ,ABT-263, gossypol, apogossypol,TW-37,obatoclax, HAl4-1 have attracted much reseach attention. Preclinical trials have shown that the inhibitors have cancer killing effect on some tumors when used alone and exhibit striking synergistic effect when combined with radiotherapy and/or chemotherapy.
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Index:
WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2010
Type:
Article