Pay more attention to the study of the relationship between diabetes mellitus and cancer / 中华内分泌代谢杂志

ABSTRACT

Diabetic patients are at increased risk of some cancers,mainly pancreatic cancer,liver cancer,colorectal cancer,breast cancer,endometrial cancer,etc.,and these cancers often result in higher mortalities than that in nondiabetics.The exact mechanism of this relationship is still unclear.The most suggested factor are hyperinsulinemia and insulin-like growth factors with their growth promoting and mitogenic effects.Recently,some insulin analogues are suspected to have these carcinogenic effects,but no firmly proven data are available yet.Metformin may have a protective effect in this regard.