Correlation of STAT3 expression with clinicopathological parameters in colorectal carcinomas / 中国综合临床

ABSTRACT

Objective To investigate the expression of STAT3 and its clinicopathological characteristics in colorectal carcinomas. Methods The expression and location of STAT3 and VEGF protein were deterimined using MaxVisionTM immunohistochemistry and immunohistochemiscal S-P method in 50 colorectal carcinomas and 30 nor-real colorectal tissues. Results Positive expression rates of STAT3 protein in colorectal cancer tissues and normal colorectal mucosa tissues were 82.0% and 33.3%. The expression of STAT3 protein was related to differentiation, TNM stage and lymph node metastasis in colorectal carcinomas (P<0.05 ). VEGF in the expression of lower tumor differentiation and highter TNM stage was significantly higher than that in higher turner differentitation and lower TNM stage (P < 0.01 ). VEGF in the groups of serosa invasion and lymph node metastasis was higher than that in no serosa invasion and lymph node metastasis ( P < 0.05 ). Conclusions STAT3 protein expression is associated with the development of colorectal carcinoma, and its overexpression is an independent adverse prognosticator in colorectal cancer. STAT3 and VEGF protein may play an important role in colorectal tumorigenesis and disease progression.