The role of 131Ⅰ in the apoptosis of thyrocytes of patient with Graves' disease / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 280-281, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-394166
ABSTRACT
The changes of Fas.FasL and Bcl-2 expression in thyrocytes of patients with Graves'disease were investigated before and 2 weeks after 131Ⅰ administration. The results showed that 131Ⅰ couhl induce thyrocytes to express the apoptotic protein Fas, FasL and the anti-apoptotic protein Bet-2 in patients with Graves'disease. A statistically significant correlation was found between the dose of 131Ⅰ and the expression levels of Fas and FasL but not Bet-2 ,suggesting that early onset of hypothyroid after 131Ⅰ administration may be due to the increased expression of Fas and FasL in thyrocytes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS