The comparative study of effects of mental stress and physiological stress on the anxiety behavior in Sprague-Dawley rats / 中华行为医学与脑科学杂志

ABSTRACT

Objective To compare the effects of mental stress and physical stress on the anxiety behavior in SD rats.Methods 24 male SD rats were allocated into mental stress group,physiological stress group and control group randomly,and the Communication Box was applied to establish animal model of mental stress,then assessed their anxiety behavior through the Open field test and elevated plus nlaze test.Results In the Open field test.the numbers of squares crossed peripherally and centrally,and the grooming frequency significantly lowered in physiological stress group and in mental stress group compared with that in control group,and were significantly higher in mental stress group than in physiological stress group.The elevated plus maze test demonstrated similar results in the numbers of open arm entries and the time spent in open arms among these three groups.Conclusion In Communication Box model,the anxiety behavior level of physiological stress mats were higher than that in mental stress rats.