SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
Journal of Veterinary Science
;
: 211-213, 2012.
Article
in English
| WPRIM
| ID: wpr-39669
ABSTRACT
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Wolves
/
Cloning, Organism
/
Ovotesticular Disorders of Sex Development
/
Nuclear Transfer Techniques
/
Karyotyping
/
Mutation
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2012
Type:
Article
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