Study on pancreatic islet β-cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation / 中华内分泌代谢杂志

ABSTRACT

The intrauterine growth retardation (IUGR) model was established by maternal nutrition restriction during mid- to late-gestation. IUGR rats had both impaired pancreatic development and islet β-cell dysfunction. As the animals grew, the rats gradually showed impaired glucose tolerance and decreased insulin sensitivity.