Liver graft induces the immune tolerance of intestinal allograft in auxiliary en-bloc Hver-small bowel transplantation in pigs / 中华消化外科杂志
Chinese Journal of Digestive Surgery
; (12): 436-438, 2008.
Article
in Zh
| WPRIM
| ID: wpr-397401
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ABSTRACT
Objective To study the effects of liver graft on the immune tolerance of intestinal allograft in auxiliary en-bloc liver-small bowel transplantation in pigs.Methods Seventy outbreed Landrace pigs were divided into 4 groups.Ten auxiliary liver-small bowel allotransplantations were performed in group A,B,C,respectively,and 5 segmental small bowel allotransplantatiom were performed in group D.Pigs were administered with routine and lower dose of cyclosporine and methylprednisolone in group B and C,respectively. No immunosuppressive agent was administered to pigs in group A and D.Results The initial time of acute rejection was obviously prolonged in group A than group D.and the acute rejection was milder in group A than group D(P<0.05).There was no significant difference upon postoperative survival time,initial time of acute rejection and degree of acute rejection between group B and C(P>0.05).Conclusions The immune tolerance of intestinal allograft Can be induced by liver graft in auxiliary en-bloc liver-small howel transplantation.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Digestive Surgery
Year:
2008
Type:
Article