Analysis on BK virus infection related factors in renal transplant recipients / 中华泌尿外科杂志

ABSTRACT

Objective To analyze the risk factors affecting BK virus(BKV)infection after kidney transplantation.Methods Taking 90 renal recipients as objectives,urine and peripheral blood (PB)samples of which were taken for the BKV cytologieal test of urinary sediment and real-time PCR tests for BKV DNA of both urine and PB at 1,3,6,9 and 12 months after transplantation.Part of the renal-recipients had been received the graft biopsy.According to BKV DNA in urine,90 recipients were divided into two groupsBKV infected group and non-BKV infected group.Potential variables were compared between the two groups and analyzed by Logistic regression model multivariate analysis to assess and rank the BKV infection related factors.Results The positive rates of urine decoy cell,BKV viruria and viremia in 90 renal recipients were 42.2%(38/90),45.6%(41/90)and 22.2%(20/90),respectively.The proportion of the recipients who used FK506+MMF protocol in the BKV infected group was 68.3%(28/41),which was higher than that of the non-BKV infected group 40.8%(20/49,P＜0.01).Using FK506+MMF protocol was the independent risk factor impacting on BKV infection in renal recipients(X2=6.579,P=0.01,OR=3.123).Five cases of BK virus associated nephropathy(BKVAN)were diagnosed.Conclusion Using FK506+MMF can increase the possibility of BKV infection and then result in BKVAN in renal transplant recipients,intensively BKV monitoring is necessary for these recipients.