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Relationship between plasminogen activator inhibitor 1 gene polymorphism and the level of endothelium-de- pendent vasodilatation in patients with type 2 diabetes / 中国综合临床
Clinical Medicine of China ; (12): 708-710, 2008.
Article in Zh | WPRIM | ID: wpr-399710
Responsible library: WPRO
ABSTRACT
Objective To investigate the relationship between the polymorphisms of plasminogen activator inhibitor-1(PAI-1)gene and the level of endothelium-dependent vasodilatation (EDF) in patients with type 2 diabe- tes(T2DM).Methods The polymorphisms of PAI-1(4G/5G)gene were determined by polymerase chain reaction (PCR)and the EDF was assessed by non-invasive hish resolution B-mode ultrasonography in 66 T2DM patients and 33 controls.Plasma plasminogen activator inhibitor type-1(PAI-1)and fibrinogen(Fg)were measured.Results Frequencies of PAI-1 alleles and genotypes in T2DM patients and controls were all in accordance with the Hardy Weinberge quilibrium,without significant differences between T2DM patients and controls(P>0.05).PAI-1 and Fg were significantly higher in T2DM patients than in controls.There were significant differences in EDF and PAI- lamong different genotypes of PAI-1(P<0.05).Conclusion The PAI-1 genotype may affect EDF in T2DM pa- tients.
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Full text: 1 Index: WPRIM Language: Zh Journal: Clinical Medicine of China Year: 2008 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Clinical Medicine of China Year: 2008 Type: Article