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Therapeutic effects of prostaglandin E1 on diabetic nephropathy in different periods in the elderly people / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 498-501, 2008.
Article in Zh | WPRIM | ID: wpr-399763
Responsible library: WPRO
ABSTRACT
Objective To investigate the effects of prostaglandin E1(PGEl)in improving proteinuria and albuminuria in the elderly people with diabetic nephropathy(DN). Methods Patients including stage Ⅲ,stage Ⅳ and stage Ⅴ were divided into four groupsconventional therapy group,PGE1 group,PGE1+ACEI group and ACEI group.Proteinuria and albuminuria were measured before and after treatment for 15 days,3 months,6 months. Results (1)In the DN patients in stage Ⅲ and stage Ⅳ (proteinuria<2.5 g/d),the proteinuria and albuminuria descended markedly in PGE1+ACEI and PGEl group(P<0.01).It was better than that in eonventionaI therapy and ACEI group.(2)In the DN patients in stage Ⅳ(proteinuria>2.5 g/d),proteinuria and albuminuria were not changed significantly after 3 months and 6 months in PGE1+ACEI and PGE1 group,but they were increased in conventional group(P<0.05).(3)In the DN patients in stage Ⅴ,the proteinuria and albuminuria were not changed much after 1 5 days,3 months and 6 months(P<0.05).The proteinuria and albuminuria were increased by more than 10 percent(P<0.01)in the conventional group after 3 and 6 months. Conclusions The therapeutic effects of PGE1 are obvious.Early treatment of nephropathy will get a better improvement in patients with diabetic nephropathy.
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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Geriatrics Year: 2008 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Geriatrics Year: 2008 Type: Article