Mycophenolate mofetil (MMF) used for treating type Ⅳ lupus nephritis and literature review / 中华风湿病学杂志
Chinese Journal of Rheumatology
; (12): 178-180, 2001.
Article
in Zh
| WPRIM
| ID: wpr-402131
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WPRO
ABSTRACT
Objective To observe about curative effect of MMF on type Ⅳ lupus nephritis and to review the literature about MMF used to treat LN.Method Ten patients with type Ⅳ LN were treated with MMF 1~2 g/d plus prednisone at middle or little dose.Curative duration of these patients was between 6 and 12 months.After 3,6 and 12 months curative effect was observed.Results After treatment proteinurie and systemic lupus activity measurement were decreased gradually.Before and after treatment ANA positive rates were 80% and 30%,anti dsDNA antibody positive rates were 50% and 10%,respectively,and low C3 and C4 was rectified.After treatment renal failure in 3 patients was recovered.During treatment major adverse reactions included gastrointestinal symptoms and herpes zoster.Conclusion MMF has exacttly effect on type Ⅳ LN and low side effect.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Rheumatology
Year:
2001
Type:
Article