Clinical application of compound injectable bone substitutes in bone injury repair / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 10117-10120, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-404622
ABSTRACT
BACKGROUND:
To summarize the feature and clinical application of various injectable bone substitutes.DATA SOURCES The computer-based research was done in Pubmed database for articles concerning various injectable bone substitutes published from January 1995 to May 2009 with the key words of "injectable bone substitute, bone injury" in titles and abstracts. Literatures of the same fields published in recent years or in authorized journals were selected.DATA SELECTION Latest literatures addressing feature and clinical application of various injectable bone substitutes were selected; old and repetitive studies were excluded. Finally, 21 articles were included.MAIN OUTCOMEMEASURES:
Feature and clinical application of various injectable bone substitutes were measured.RESULTS:
Present various injectable bone substitutes contained complex hydroxyapatite bone substitutes, complex calcium sulfate bone substitutes, and complex calcium phosphate bone substitutes. Addition of bone morphogenetic protein-2 etc. in injectable bone substitute could significantly elevate bone union speed, promote osteoblastic proliferation, and overcome disadvantage of physical bone substitute to some degrees. Addition of platelet-rich plasma could promote repair effect of injectable bone substitute on bone defects, and promote differentiation of bone marrow stromal stem cells and proliferation of osteoblasts. Addition of cells could make up the insufficiency of physical materials to great degrees.CONCLUSION:
The compound injectable bone substitute has a bright perspective of clinical application. Injectable bone substitutes combined with cells (especially stem cells) will be a new direction for biomaterial development in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2009
Type:
Article
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