Study on testicular pathological change, lipid peroxidation and nitric oxide in diabetic rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12): 425-427, 2001.
Article
in Zh
| WPRIM
| ID: wpr-410417
Responsible library:
WPRO
ABSTRACT
AIM:To study testicular pathological change and its pathogenesis. METHODS:Testicular structure of alloxan induced diabetic rats was observed under light microscopy (LM)and transmission electron microscopy(TEM). Activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),nitric oxide synthase(NOS)and content of malondialdehyde (MDA),nitric oxide(NO) were detected biochemically in testicular homogenate. RESULTS:It is manifestated as atrophy of seminiferous tubule and germinal arrest under LM and expansion of mitochondria and smooth endoplasmic reticulum, cytoplasmic inclusion of sertoli cell under TEM.Activity of SOD, GSH-PX decreased while activity of NOS, content of MDA, NO increased in diabetic rats compared with control one. CONCLUSION:Disturbance of spermatogenesis and damage of sertoli cell are the main morphological change of diabetic testis, lipid peroxidation and NO may be involved in it.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Pathophysiology
Year:
2001
Type:
Article