Resolution of Racemic Thyroxine with Chiral Additive asMobile Phase by High Performance Liquid Chromatography / 分析化学
Chinese Journal of Analytical Chemistry
;
(12): 406-409, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410551
ABSTRACT
A high performance liquid chromatographic (HPLC) method using triethylamine (TEA), copper *" acetate and L-proline as the chiral mobile phase (CMP) and the enantiomric analysis of thyroxine (T4) are described. The influence of the mobile phase parameters including the TEA concentration, manipulation pH, concentration of Cu*", concentration of L-proline, temperature of column and flow rate of eluent on the enantiomers separation of thyroxine was studied. The HPLC-CMP is a simple method for separation and determination of D,L-T4 in drug or in human plasma. It can be used to therapeutic drug or adverse drug reactions monitor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Analytical Chemistry
Year:
2001
Type:
Article
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