Determination of Aconitine alkaloids in Aconitum Plants andRelated Proprietary Medicines byLiquid Chromatography/Mass Spectrometry/Mass Spectrometry / 分析化学

ABSTRACT

for the determination of aconitine, mesaconitine and hypaconitine in root tuber of sevral species of Aconitum plants and related proprietary medicines. With the use of the optimized instrumental conditions and the Multiple Reaction Monitoring (MRM) technique, good linearity was obtained for the alkaloids in concentrations ranged from 0.5 to 40 mg/L. The method was applied to the analysis of 14 samples of various species of Aconitum plants and 10 different proprietary medicine samples