Expression of tumor suppressor gene-p33/ING1 in colorectal carcinoma / 第三军医大学学报
Journal of Third Military Medical University
; (24): 349-351, 2001.
Article
in Zh
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| ID: wpr-410673
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ABSTRACT
Objective To explore the correlation between the expression of p33/ING1 and the clinicopathological features in patients with colorectal cancer, and to understand the possible mechanism of p33/ING1 in the oncogenesis of colorectal neoplasms. Methods All samples of normal mucosa and cancer tissues from 52 patients with colorectal cancer were detected for their expression levels of p33/ING1 by RT-PCR. Results A significant decrease in p33/ING1 mRNA expression was found in 30 out of 52(57.7%) colorectal cancer tissues. The results also showed that repression of p33/ING1 expression markedly related to both the Duke's stage and metastasis. Conclusion Down-regulation of p33/ING1 may play an important role in the oncogenesis and development of colorectal carcinoma.
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Language:
Zh
Journal:
Journal of Third Military Medical University
Year:
2001
Type:
Article