Comparison of Dissolubility of Lansoprazole Enteric- coated Tablets With That of Enteric- coated Capsules / 中国药房
China Pharmacy
;
(12): 171-172, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410952
ABSTRACT
OBJECTIVE: To study the method of measuring the in vitro dissolubility of lansoprazole enteric- coated tablets and to find out the difference between the dissolubility of lansoprazole enteric- coated tablets and that of lansoprazole enteric- coated capsules.METHODS: To establish a measuring method of the dissolubility of lansoprazole enteric- coated tablets and compare the dissolubility of lansoprazole enteric- coated tablets with that of lansoprazole enteric- coated capsules and to acquire the dissolving parameters for variance analysis.RESULTS: (1)The accumulative dissolving quantity of the both preparations exceeded 80% in 30 minutes.(2)The comparison of Weibull parameters,T50,Td and m,between each other in group A showed no significant differences(P>0.05).It was the same for those of group B.(3)The parameters,T50 and Td,of group A,in comparison with those of group B,showed significant differences(P<0.001).The times needed for dissoiving 50% and 63.2% of quantity in group B were both shorter than those in group A.The m parameters in different groups had no significant differences(P>0.05).There was no significant difference in slope of equation between two groups.CONCLUSION: This measuring method of the in vitro dissolubility of lansoprazole enteric- coated tablets is simple,convenient,accurate,stable,feasible and good in repetition.It is concluded that there is significant difference between the dissolubility of the two dosage forms of enteric- coated preparation of lansoprazole.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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