Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases / 医学研究生学报

ABSTRACT

Objectives:To evaluate the relationship between the activity of cholesteryl ester transfer protein(CETP) and cardiocerebrovascular diseases.　Methods:The CETP activity of 45 cases of coronary heart disease(CHD) and 26 cases of stroke were measured using the synthetic substrate of 14　C-radiolabeled discoidal bilayer particles as the cholesteryl ester donor and LDL as receptor.　Results:The CEPT activity(x±s) of CHD and stroke patients were(17.6±5.4)% and(15.2±3.8)%,while the healthy controls were(12.7±2.0)%.The CEPT activities in CHD and stroke patients were significantly higher than that in healthy controls(P<0.01).　Conclusions: CETP is related to the occurrence and development of atherosclerosis.