Effects of chitosan/modified chitosan DNA nanoparticles on the differentiation of human naive CD4+ T cells / 国际生物医学工程杂志
International Journal of Biomedical Engineering
;
(6): 91-93, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-415850
ABSTRACT
Objective To investigate the impact of chitosan and alkylated chitosan DNA nanoparticles on the function of human naive CD4+T cells.Methods The secretion of cytokines (IL-4 and TNF-γ) was observed after the co-incubation of human naive CD4+T cells with nanoparticles 12 h,24 h and 48 h,respectively.ResultsNone of the nanoparticles induced the production of cytokines ( IL-4 and TNF-γ ).Conclusion Chitosan and alkylated chitosan DNA nanoparticles will not induce the differentiation of human naive CD4+ T cells into T1 or T2 and may be considered as a safe gene carrier.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Biomedical Engineering
Year:
2011
Type:
Article
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