Advances of tumor-associated fibroblasts in carcinogenesis / 国际肿瘤学杂志

ABSTRACT

Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor.Tumor-associated fibroblasts (TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors.