A Case of Intravascular Large B Cell Lymphoma / 대한피부과학회지

ABSTRACT

Intravascular large cell lymphoma (angiotropic large cell lymphoma) is a rare, multifocal, intravascular neoplasm of lymphoid cells that preferentially involves the vasculature of the skin and central nervous system. We report a 33-year-old man who had asymptomatic purpuric patches on both thighs, left arm, and left flank. A biopsy specimen showed intravascular collections of tumor cells with irregular nuclear contour and prominent nucleoli. These cells were positive for CD45, CD20, but negative for CD3, and CD56. The clinicopathologic features and immunohistochemical profiles were diagnostic of intravasculr large B cell lymphoma.