The correlation between the OATP1B1 521T > C genetic polymorphism and essential hypertension / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 646-648, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-425420
ABSTRACT
Objective To study the relationship between the OATP1B1 521T > C genetic polymorphism and essential hypertension.Methods 164 essential hypertension subjects and 159 normotensive subjects were detected by the TaqMan-MGB probe real-time fluorescence quantitative PCR,and the results were compared with those of DNA sequencing.Results The frequencies of T/C genotype and C allele of OATP1B1 521T > C gene of the essential hypertension subjects were obviously lower than those of the normotensive subjects(T/C genotype0.16 vs 0.25,P <0.05 ;C allele0.10 vs 0.17,P <0.05),The difference was significant.Binary logistic stepwise regression analysis was used for evaluatine the risk factors of essential hypertension,there was significant relationship between OATP1 B1 52IT > C gene polymorphism and essential hypertension.Conclusion The SLCO1 B1 521T > C variant was common in Chinese essential hypertension population,but the difference of frequency of SLCO1B1 52IT > Cmuton between the essential hypertension patients and the normotensive controls was of obviously statistical significance,which indicates that the SLCO1B1521T > C variant maybe associate with essential hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2012
Type:
Article
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