A study of prospective memory in patients with late-onset depression / 中华行为医学与脑科学杂志

ABSTRACT

ObjectiveTo investigate the event-based prospective memory (EBPM)and time-based prospective memory( TBPM )in late-onset depressive patients and to explore the relationships between prospective memory and depressive symptoms.Methods 32 late-onset depressive patients and 30 normal controls matched in age,gender and education were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks.The patients were also assessed with Hamilton Depression Scale (HAMD).ResultsA statistically significant in EBPM was observed between patients with late-onset depression and normal controls (2.31 ± 1.06 vs 3.07± 0.87,t =- 3.052,P ＜ 0.01) and the same result in TBPM (2.03 ± 0.93 vs 2.67 ± 0.92,t =- 2.695,P ＜0.01 ).The negatively correlate was showed between the total scores of HAMD and EBPM ( r =- 0.436,P =0.013 ),TBPM ( r =- 0.467,P =0.007 ) in the patients.ConclusionThe results suggest late-onset depressive patients impair both EBPM and TBPM.Prospective memory shows correlation with depressive symptoms in the patients.