Inhibition mechanism of vitamin D in lung cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 594-597, 2012.
Article
in Zh
| WPRIM
| ID: wpr-427736
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WPRO
ABSTRACT
In recent years a large number of studies have been conducted to investigate the role of vitamin D and its metabolites in cancer.However,the picture for lung cancer is not clear at the present time.There are three integral components of the vitamin D pathway:the vitamin D receptor(VDR),CYP27B1 and CYP24A1.Besides,vitamin D inhibits the carcinogenesis of lung by indirectly influencing IGF signaling,TGF-β signaling,and Wnt/β-catenin signaling pathway.Their differential expressions in normal lung tissue and lung cancer offer clues and lay the foundation for research of the inhibitory function in lung cancer pathogenesis.
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WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2012
Type:
Article