Metabolism of amino acids and type 2 diabetes mellitus / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 773-776, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-427980
ABSTRACT
Amino acids (AA) as substrates of gluconeogenesis could promote endogenous glucose production.Some AA can enhance insulin secretion. Recently,many studies have found that some AA can also activate mammalian target of rapamycin-S6 kinase 1 ( mTOR-S6K1 ) pathway,resulting in maintaining pancreatic β cell function on one hand,and on the other hand,inhibiting insulin signal transduction of insulin-sensitive cells and thus causing insulin resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2012
Type:
Article
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