Empiric initial therapy in peritoneal dialysis-related peritonitis / 中华肾脏病杂志
Chinese Journal of Nephrology
; (12): 899-902, 2011.
Article
in Zh
| WPRIM
| ID: wpr-428242
Responsible library:
WPRO
ABSTRACT
Objective To investigate the pathogens,drug resistance and outcomes of continuous ambulatory peritoneal dialysis(CAPD) patients with peritoneal dialysis-related peritonitis in our peritoneal dialysis(PD) centers. Method Data including clinical manifestations,pathogens,treatment,outcome of 93 CAPD cases with peritoneal dialysis-related peritonitis in our peritoneal dialysis(PD) centers were retrospectively analyzed.Results Dialysate culture of 75cases was positive with a positive rate of 80.2%,including 45 cases of gram-positive cocci,21cases of gram-negative bacilli,2 cases of fungi and 5 cases of mixed infection.Coagulase-negative staphylococci were the most common gram-positive cocci.All the gram-positive cocci were sensitive to vancomycin,but the resistance rate to cefazolin was 60.0% with an increasing tendence year by year.Resistance rate of gram-negative bacilli to ceftazidime was 46.1%.All the gram-negative bacilli were sensitive to imipenem.The withdraw rate of CAPD was 17.2%(16/93) because of peritonitis. Noobviousside-effectofperitonealadministrationofvancomycinwasfound.Conclusions Gram-positive cocci are major pathogens in CAPD-related peritonitis.Now cefasolin is not suitable for the empiric initial treatment.Peritoneal administration of vancomycin should be recommended for peritonitis caused by gram-positive cocci.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Nephrology
Year:
2011
Type:
Article