The Role of Whole-Body FDG PET/CT, Tc 99m MDP Bone Scintigraphy, and Serum Alkaline Phosphatase in Detecting Bone Metastasis in Patients with Newly Diagnosed Lung Cancer
Journal of Korean Medical Science
; : 275-280, 2009.
Article
in En
| WPRIM
| ID: wpr-42859
Responsible library:
WPRO
ABSTRACT
Bone scan (BS) and serum alkaline phosphatase (ALP) concentration are used to detect bone metastasis in malignancy, although whole-body fluoro-D-glucose positron emission tomography computed tomography (FDG PET/CT) is being used increasingly. But BS is still used for the detection of metastatic bone lesion. So we compared the usefulness of PET/CT, BS, and serum ALP in detecting bone metastases in patients with newly diagnosed lung cancer. The medical record database was queried to identify all patients with a new diagnosis of lung cancer between January 2004 and December 2005, who had a PET/CT, BS, and serum ALP before treatment. We retrospectively reviewed all patients' records and radiological reports. One hundred eighty-two patients met the inclusion criteria. Bone metastases were confirmed in 30 patients. The sensitivity values were 93.3% for PET/CT, 93.3% for BS, 26.7% for serum ALP concentration, and 26.7% for BS complemented with serum ALP concentration. The respective specificity values were 94.1%, 44.1%, 94.1%, and 97.3%. The kappa statistic suggested a poor agreement among the three modalities. FDG PET/CT and BS had similar sensitivity, but PET/CT had better specificity and accuracy than BS. PET/CT is more useful than BS for evaluating bone metastasis. However, in the advanced stage, because of its high specificity, BS complemented with serum ALP is a cost-effective modality to avoid having to use PET/CT.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Bone Neoplasms
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Tomography, X-Ray Computed
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Technetium Tc 99m Medronate
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Medical Records
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Retrospective Studies
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Sensitivity and Specificity
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Carcinoma, Small Cell
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Carcinoma, Non-Small-Cell Lung
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Radiopharmaceuticals
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Fluorodeoxyglucose F18
Type of study:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limits:
Aged
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Female
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Humans
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Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article