Neurokinin B and its receptor in idiopathic hypogonadotropic hypogonadism / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 88-90, 2013.
Article
in Zh
| WPRIM
| ID: wpr-431188
Responsible library:
WPRO
ABSTRACT
Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by delayed or absent puberty and lowered sexual function as a result of impaired pulsatile gonadotropin-realeasing hormone (GnRH) secretion.Identification of TAC3/TACR3 mutations as the culprits of IHH revealed that neurokinin B (NKB) signaling pathway was involved in the regulation of pulsatile GnRH secretion.This review focuses on the involvement of NKB signaling in pulsatile GnRH release,the discovery of TAC3/TACR3 mutations and the phenotypes,and treatment of patients who carry TAC3 or/and TACR3 mutations.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2013
Type:
Article