Efficacy and safety of Danhong injection in treatment of angina pectoris: a Meta-analysis / 中华全科医师杂志

ABSTRACT

To analyze the efficacy and safety of Danhong injection in treatment of angina pectoris.Literatures of randomized controlled trials on efficacy comparison of Danhong injection and its components in the single herb pharmaceutical preparations (Danshen injection,safflower injection and compound Danshen injection) for patients with angina pectoris due to coronary heart disease were extracted from database including Wan Fang,CNKI,VIP,for all medical publications between 2000 and 2010.Meta-analysis was performed.The Meta-analysis included total 1306 patients in the treatment group of Danhong injection and 1280 patients in the control group from 28 clinical trials.The results showed that clinical effect and electrocardiogram efficacy in Danhong injection group were significantly better than those in control group (RR =1.23,95％ CI1.19-1.27 and RR =1.29,95％ CI1.22-1.37,respectively).The homogeneity of the total effective rate was good; however,there had a great variation in hemorrheologic and the serum lipids indices.Thirteen literatures reported that there was no obvious adverse reaction found in Danhong injection group; 9 literatures did not report adverse reaction.Danhong injection has a significant therapeutic effect and safety in patients with angina pectoris due to coronary heart disease.